The purpose of this study was to see if feeling grateful to God reduces the deleterious effects of stress on health in late life. In addition, an effort was made to test for gender differences in this process. Three main findings emerged from the analysis of data provided by a nationwide sample of older adults. First, the data suggest that older women are more likely to feel grateful to God than older men. Second, the results revealed that the effects of stress (e.g., living in a deteriorated neighborhood) on health are reduced for older people who feel more grateful to God. Finally, the analyses indicated that the potentially important stress-buffering properties of gratitude toward God emerge primarily among older women but not older men.