Using specimens from a population-based case control study among women ages 18 to 44 years in western Washington, we assessed the relationship between carriership of a genetic clotting factor II variant (20210 G→A) and myocardial infarction (MI). The factor II variant was previously shown to be present in 1% to 2% of the population, to… Continue reading A Common Prothrombin Variant (20210 G to A) Increases the Risk of Myocardial Infarction in Young Women

Factor V Leiden (factor V Arg506Gln), the genetic defect underlying resistance to activated protein C, is the most common risk factor for venous thrombosis. The relationship between this genetic abnormality and arterial disease is still unresolved. To assess whether factor V Leiden increases the risk of myocardial infarction (MI), we conducted a population-based case-control study… Continue reading Factor V Leiden (Resistance to Activated Protein C) Increases the Risk of Myocardial Infarction in Young Women

BACKGROUND:There is evidence of a contribution of early life socioeconomic exposures to the risk of chronic diseases in adulthood. However, extant studies investigating the impact of the neighborhood social environment on health tend to characterize only the current social environment. This in part may be due to complexities involved in obtaining and geocoding historical addresses.… Continue reading Historical measures of social context in life course studies: retrospective linkage of addresses to decennial censuses

Attitudes toward surveys were conceptualized as having two relatively independent components: feelings about the act of completing a survey, called survey enjoyment, and perceptions of the value of survey research, called survey value. After developing a psychometrically sound measure, the authors examined how the measure related to respondent behaviors that directly impact the quality and… Continue reading Attitudes toward Surveys: Development of a Measure and Its Relationship to Respondent Behavior

Increased left ventricular mass (LVM) and lower socioeconomic status (SES) are predictors of cardiovascular morbidity and mortality. Blacks and Hispanics are more likely to have higher LVM and lower SES. The relation between SES, race-ethnicity, and LVM has not been fully explored. Data were used from the NOMAS population-based sample of 1916 subjects living in… Continue reading Relation Between Socioeconomic Status, Race-Ethnicity, and Left Ventricular Mass: The Northern Manhattan Study