Recent evidence suggests that a genetic polymorphism in the promoter region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) mediates stress reactivity in adults. Little is known, however, about this gene-brain association in childhood and adolescence, generally conceptualized as a time of heightened stress reactivity. The present study examines the association between 5-HTTLPR allelic variation and… Continue reading Neural and behavioral responses to threatening emotion faces in children as a function of the short allele of the serotonin transporter gene
Keyword: Genome-Wide Association Study
Genetic studies of body mass index yield new insights for obesity biology
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of… Continue reading Genetic studies of body mass index yield new insights for obesity biology
GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy
BACKGROUND: The genetic contribution to longevity in humans has been estimated to range from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with longevity in multiple independent studies. METHODS: We conducted a meta-analysis of genome-wide association studies including 6,036 longevity cases, age >/=90 years, and 3,757 controls that died between ages… Continue reading GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy