IMPORTANCE/OBJECTIVE: Although the suicide rate in the U.S. Army has traditionally been below age-gender matched civilian rates, it has climbed steadily since the beginning of the Iraq and Afghanistan conflicts and since 2008 has exceeded the demographically matched civilian rate. The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) is a multicomponent… Continue reading The Army study to assess risk and resilience in servicemembers (Army STARRS)
Keyword: Case-Control Studies
Neural activation to emotional faces in adolescents with autism spectrum disorders
BACKGROUND: Autism spectrum disorders (ASD) involve a core deficit in social functioning and impairments in the ability to recognize face emotions. In an emotional faces task designed to constrain group differences in attention, the present study used functional MRI to characterize activation in the amygdala, ventral prefrontal cortex (vPFC), and striatum, three structures involved in… Continue reading Neural activation to emotional faces in adolescents with autism spectrum disorders
Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
CONTEXT: Considerable work implicates abnormal neural activation and disrupted attention to facial-threat cues in adult anxiety disorders. However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues. OBJECTIVE: To determine whether attention modulates amygdala and cortical responses to facial-threat cues differentially in adolescents with generalized anxiety disorder and in… Continue reading Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
Common and distinct amygdala-function perturbations in depressed vs anxious adolescents
CONTEXT: Few studies directly compare amygdala function in depressive and anxiety disorders. Data from longitudinal research emphasize the need for such studies in adolescents. OBJECTIVE: To compare amygdala response to varying attention and emotion conditions among adolescents with major depressive disorder (MDD) or anxiety disorders, relative to adolescents with no psychopathology. DESIGN: Case-control study. SETTING:… Continue reading Common and distinct amygdala-function perturbations in depressed vs anxious adolescents