Background The objective of this study was to evaluate the existence of cognitive plateaus in some individuals during the course of Alzheimer’s disease (AD).Methods Data came from the historical patient group collected via the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD, Duke University, 1988�1996). Data reduction was performed by using principal components analysis… Continue reading The existence of cognitive plateaus in Alzheimer’s disease
Keyword: Alzheimer's Disease
“Below average” self-assessed school performance and Alzheimer’s disease in the Aging, Demographics, and Memory Study
Background A low level of formal education is becoming accepted as a risk factor for Alzheimer’s disease (AD). Although increasing attention has been paid to differences in educational quality, no previous studies addressed participants’ own characterizations of their overall performance in school. We examined whether self-assessed school performance is associated with AD beyond the effects… Continue reading “Below average” self-assessed school performance and Alzheimer’s disease in the Aging, Demographics, and Memory Study
Distinguishing Preterminal and Terminal Cognitive Decline
This paper reviews different methodological approaches taken to examine terminal decline in cognitive function, and presents new findings from the Bronx Aging Study (BAS). Numerous approaches have been taken to assess mortality effects on cognition: comparing survivors and decedents level and rate of change in cognition, and identifying individual differences in cognition associated with time-to-death.… Continue reading Distinguishing Preterminal and Terminal Cognitive Decline
Mixed dementia: Emerging concepts and therapeutic implications
Vitamin D, Cognitive Dysfunction and Dementia in Older Adults
The physiologically active form of vitamin D, 1,25-dihydroxyvitamin D3, is a fat-soluble steroid hormone with a well established role in skeletal health. A growing body of evidence suggests low vitamin D levels also play a role in the pathogenesis of a wide range of non-skeletal, age-associated diseases including cancer, heart disease, type 2 diabetes mellitus… Continue reading Vitamin D, Cognitive Dysfunction and Dementia in Older Adults