Little is known about the extent to which the biological embedding of promotive and protective factors pre-loads a capacity for resilience across the life course. If researchers better understood how promotive and protective factors operate biologically we could better determine what causes depression, which children are most at risk, and perhaps most critically, the optimal times to intervene to delay (or prevent) first onsets of depression. We will address these gaps by discovering epigenetically-linked processes and time periods when positive life experiences promote resilience to depression.