This NSF-RAISE proposal, ?Neighborhood Environments as Socio-Techno-bio Systems: Water Quality, Public Trust, and Health in Mexico City (NESTSMX)?, is a four-year collaborative, interdisciplinary project that brings together methodological expertise in three broad areas?environmental engineering, cultural anthropology, and epidemiology. The combination of these three areas of expertise necessary for our multidimensional approach makes NESTSMX an unlikely candidate for funding within a single NSF program. The overarching goal of NESTSMX is to develop methodological tools to understand neighborhoods as social-technical-biological systems, as well as building on and expanding several interrelated social-scientific, environmental engineering, and epidemiology literatures that seek to understand phenomena as produced through dynamic interlinked systems.