The K01 proposal seeks to provide an early career educational neuroscientist (Dr. Suzanne Perkins) with the training, mentorship, and resources to fill the gap in the need for translational and transdisciplinary researchers in childhood maltreatment (CM) who can navigate between neuroscience and social welfare to bring needed intervention to this population. This award will provide the necessary support to launch her independent scientific career focused on CM using advanced neuroscience methods to delineate cognitive developmental neural mechanisms for children that experience childhood maltreatment leading to cognitive functioning deficits. The candidates scientific goal is to define the brain basis of adverse cognitive consequences of CM, refine a mechanistic theory, and develop mechanism-targeted interventions for early preventative care for this population. Although there has been great progress in understanding the role of early life adversities (ELA) on the development of psychopathology, there is limited research on behavioral and neuroscience models of academic deficits in this population. In the proposed project, the candidate will harness her expertise as a former special educator to identify CM neural patterns in a large adolescent sample of normative development (ABCD) and a newly acquired substantiated CM sample, develop best practices neuroscience methods for smaller CM-specific cohorts, test a mechanistic theory, and develop a preliminary brain-based cognitive intervention for children with a history of CM. To examine the proposed neurobiological model of CM, a series of multivariate predictive models of neuropsychological and task-based measures of cognition will be conducted using Network Contingency Analysis (NCA) with principal component reduced data and a leave one-site-out cross-validation framework.